This report focuses on trends in deaths due to injury and poisoning that occurred over the period 1999–00 to 2009–10 and shows that: The age-standardised rate of injury deaths decreased by an average of 3% per year between 1999–00 and 2004–05 and changed little after that; Rates of injury deaths involving transport injury, drowning, thermal injury, suicide and homicide, tended to decline from 1999–00 to 2007–08, while rates of poisoning deaths involving pharmaceuticals fell sharply to 2001–02 before rising again; Rates for Aboriginal and Torres Strait Islander people were 2 to 3 times as high as rates for Other Australians over the period from 1999–00 to 2007–08.